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Exposure to LOXL4 results in macrophages within the TME adopting an immunosuppressive phenotype primarily mediated by interferon (IFN)-dependent signal transduction, which leads to transcription-dependent PD-L1 activation
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So, cysteinylated proteins taken up from the plasma by micropinocytosis can constitute a source of cysteine that once in the cell will be used in the different cysteine metabolic pathways, even in the s -cysteinylation of other proteins
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